学习经历

1) 2003.09-2007.06 华中农业大学，生命科学技术公司，学士

2) 2007.09-2012.12 华中农业大学，生命科学技术公司，博士

主要工作经历与任职情况

1) 2013.01-2013.12  华中农业大学，科研助理

2) 2014.01-2018.12  威斯康星大学-麦迪逊分校，博士后

3) 2019.01-至今，    yl6776永利集团官网，杂交水稻国家重点实验室，研究员

主要研究领域及兴趣

1. 植物是如何感知和耐受高温的。全球变暖和极端高温天气对粮食生产造成了严重的威胁，我们期望通过对植物响应和耐受高温的分子机制的解析，为提高农作物的耐高温提供理论支持。

2. 表观遗传在植物逆境响应和耐受中的调控机制。表观遗传是中心法则中遗传信息传递的关键调控因素。我们以植物高温应答基因的调控为切入点，深入解析表观遗传修饰在RNA的转录、加工和翻译中的精细调控机制，并进一步探究表观遗传修饰的遗传记忆和获得性遗传的可能性及其机理。

承担课程/ Teaching：

本科生：遗传学

研究生：高等遗传学

课题项目

国家自然科学基金（2020-2023；2025-2028，主持）

国家重点研发计划青年科学家项目（2023-2028，骨干）

湖北省杰出青年基金（2024-2027，主持）

中央高校自主科研项目（2020-2021，主持）

主要论文（#共同作者，*通讯作者）：

17. Zheng X, Zuo Z, Yao P, Li X, Zhang Q, Chen X*. Bromodomain-containing proteins interact with a noncanonical RNA polymerase Ⅱ kinase to maintain gene expression upon heat stress. Nature Plants. 2025; In press.
16. Du X^#, Sun Y^#, He Y, Cai H*, Chen X*. Epigenetic regulation of jasmonic acid signaling contributes to heat tolerance in rice Nagina22. aBiotech. 2025; In press.
15. Xue Y*, Cao X*, Chen X*, Deng X*, Deng XW*, Ding Y*, Dong A*, Duan CG*, Fang X*, Gong L*, Gong Z*, Gu X*, He C*, He H*, He S*, He XJ*, He Y*, He Y*, Jia G*, Jiang D*, Jiang J*, Lai J*, Lang Z*, Li C*, Li Q*, Li X*, Liu B*, Liu B*, Luo X*, Qi Y*, Qian W*, Ren G*, Song Q*, Song X*, Tian Z*, Wang JW*, Wang Y*, Wu L*, Wu Z*, Xia R*, Xiao J*, Xu L*, Xu ZY*, Yan W*, Yang H*, Zhai J*, Zhang Y*, Zhao Y*, Zhong X*, Zhou DX*, Zhou M*, Zhou Y*, Zhu B*, Zhu JK*, Liu Q*. Epigenetics in the modern era of crop improvements. Sci China Life Sci. 2025; 68(6):1570-1609.
14. Yao P, He Q, Wang Y, Sun D, Chen X*, Lu L*. Genome-wide profiling and functional study of short N-terminal H2B variants in Arabidopsis. Journal of Advanced Research. 2024; S2090-1232(24)00557-5.
13. Liu X, Cheng W, Yao P, Ren K, Wang Y, Sun Y, Hou X, Lu L, Chen X*. Conserved serine phosphorylation regulates histone deacetylase activity in Arabidopsis and humans. Plant Physiology. 2024; 194(4):2017-2021.
12. Yang F, Sun Y, Du X, Chu Z, Zhong X, Chen X*. Plant-specific histone deacetylases associate with ARGONAUTE4 to promote heterochromatin stabilization and plant heat tolerance. New Phytologist. 2023; 238(1):252-269.
11. Zhou Q, Sun Y, Zhao X, Yu Y, Cheng W, Lu L, Chu Z, Chen X*. Bromodomain-containing factor GTE4 regulates Arabidopsis immune response. BMC Biology. 2022; 20(1):256.
10. Chen X*, Ding AB, Zhong X*. Functions and mechanisms of plant histone deacetylases. Sci China Life Sci. 2020; 63(2):206-216.
9. Yang L^#, Chen X^#, Wang Z, Sun Q, Hong A, Zhang A, Zhong X*, Hua J*. HOS15 and HDA9 negatively regulate immunity through histone deacetylation of intracellular immune receptor NLR genes in Arabidopsis. New Phytologist. 2020; 226(2):507-522.
8. Mayer KS^#, Chen X^#, Sanders D, Chen J, Jiang J, Nguyen P, Scalf M, Smith LM, Zhong X*. HDA9-PWR-HOS15 is a core histone deacetylase complex regulating transcription and development. Plant Physiology. 2019; 180(1):342-355.
7. Lu L^#, Chen X^#, Qian S, Zhong X*. The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution. Nat Communications. 2018; 9(1):630.
6. Chen X, Lu L, Qian S, Scalf M, Smith LM, Zhong X*. Canonical and Noncanonical Actions of Arabidopsis Histone Deacetylases in Ribosomal RNA Processing. Plant Cell. 2018; 30(1):134-152.
5. Chen X, Lu L, Mayer KS, Scalf M, Qian S, Lomax A, Smith LM, Zhong X*. POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in Arabidopsis. eLife. 2016; 5: e17214.
4. Chen X, Liu X, Zhao Y, Zhou DX*. Histone H3K4me3 and H3K27me3 regulatory genes control stable transmission of an epimutation in rice. Sci Rep. 2015; 5:13251.
3. Chen X, Zhou DX*. Rice epigenomics and epigenetics: challenges and opportunities. Curr Opin Plant Biol. 2013; 16(2):164-9.
2. Chen Q^#, Chen X^#, Wang Q, Zhang F, Lou Z*, Zhang Q*, Zhou DX*. Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. PLoS Genetics. 2013; 9(1):e1003239.
1. Chen X, Hu Y, Zhou DX*. Epigenetic gene regulation by plant Jumonji group of histone demethylase. Biochim Biophys Acta. 2011; 1809(8):421-6.

其他论文：

14. Li W, Zhang X, Zhang Q, Li Q, Li Y, Lv Y, Liu Y, Cao Y, Wang H, Chen X, Yang H. PICKLE and HISTONE DEACETYLASE6 coordinately regulate genes and transposable elements in Arabidopsis. Plant Physiology. 2024; 196(2):1080-1094.
13. Wang X, Ju Y, Wu T, Kong L, Yuan M, Liu H, Chen X, Chu Z. The clade III subfamily of OsSWEETs directly suppresses rice immunity by interacting with OsHMGB1 and OsHsp20L. Plant Biotechnol J. 2024; 22(8):2186-2200.
12. Xuan H, Shi N, Chen J, Jiang Y, Zhang H, Chu C, Li S, Chen X, Yang H. Physical coupling of H3K4me3 demethylases and Polycomb repressive complex 2 to accelerate flowering in rice. Plant Physiology. 2024;  195(3):1802-1806.
11. Wu T, Bi Y, Yu Y, Zhou Z, Yuan B, Ding X, Zhang Q, Chen X, Yang H, Liu H, Chu Z. Activated Expression of Rice DMR6-like Gene OsS3H Partially Explores the Susceptibility to Bacterial Leaf Streak Mediated by Knock-Out OsF3H04g. Int J Mol Sci. 2023; 24(17):13263.
10. Cheng W, Fang X, Guan Z, Yao Y, Xu Z, Bi Y, Ren K, Li J, Chen F, Chen X, Ma W, Chu Z, Deng Z, Zhang Z, Lu L. Functional characterization and structural basis of a reversible glycosyltransferase involves in plant chemical defence. Plant Biotechnol J. 2023; 21(12):2611-2624.
9. Zhang X, Li W, Liu Y, Li Y, Li Y, Yang W, Chen X, Pi L, Yang H. Replication protein RPA2A regulates floral transition by cooperating with PRC2 in Arabidopsis. New Phytol. 2022 Sep;235(6):2439-2453.
8. He Y, Zhu M, Li Z, Jiang S, He Z, Xu S, Chen X, Hu Z, Zhang Z*. IPA1 Negatively Regulates Early Rice Seedling Development by Interfering with Starch Metabolism via the GA and WRKY Pathways. Int J Mol Sci. 2021; 22(12):6605.
7. Lu Y, Tan F, Zhao Y, Chen X, Zhou S, Hu Y, Zhou DX*. A Chromodomain-Helicase-DNA-like Binding Factor Functions in Chromatin Modification and Gene Regulation. Plant Physiology. 2020;183(3):1035-1046.
6. Hu Y*, Lai Y, Chen X, Zhou DX, Zhao Y. Distribution pattern of histone marks potentially determines their roles in transcription and RNA processing in rice. J Plant Physiology. 2020; 249:153167.
5. Yang Z^#, Qian S^#, Scheid RN, Lu L, Chen X, Liu R, Du X, Lv X, Boersma MD, Scalf M, Smith LM, Denu JM, Du J*, Zhong X*. EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis. Nature Genetics. 2018; 50(9):1247-1253.
4. Kim YJ, Wang R, Gao L, Li D, Xu C, Mang H, Jeon J, Chen X, Zhong X, Kwak JM, Mo B, Xiao L, Chen X*. POWERDRESS and HDA9 interact and promote histone H3 deacetylation at specific genomic sites in Arabidopsis. PNAS. 2016; 113(51):14858-14863.
3. Lu L, Chen X, Sanders D, Qian S, Zhong X*. High-resolution mapping of H4K16 and H3K23 acetylation reveals conserved and unique distribution patterns in Arabidopsis and rice. Epigenetics. 2015; 10(11):1044-53.
2. Li T, Chen X, Zhong X, Zhao Y, Liu X, Zhou S, Cheng S, Zhou DX*. Jumonji C domain protein JMJ705-mediated removal of histone H3 lysine 27 trimethylation is involved in defense-related gene activation in rice. Plant Cell. 2013; 25(11):4725-36.
1. Qin F, Sun Q, Huang L, Chen X, Zhou DX*. Rice SUVH histone methyltransferase genes display specific functions in chromatin modification and retrotransposon repression. Molecular Plant. 2010; 3(4):773-82.

招生招聘

常年接受博士后申请；每年计划招收2名硕士，1名博士，报考请选择遗传学专业方向。